Number of publication:   033/2018-BGIA

Author:		Schmitt, J.; Haufe, E.; Trautmann, F.; Schulze, H.J.; Elsner, P.; Drexler, H.; Bauer, A.; Letzel, S.; John, S.M.; Fartasch, M.; Brüning, T.; Seidler, A.; Dugas-Breit, S.; Gina, M.; Weistenhöfer, W.; Bachmann, K.; Bruhn, I.; Lang, B.M.; Bonness, S.; Allam, J.P.; Grobe, W.; Stange, T.; Westerhausen, S.; Knuschke, P.; Wittlich, M.; Diepgen, T.L.
Title:		Occupational UV-Exposure is a Major Risk Factor for Basal Cell Carcinoma: Results of the Population-Based Case-Control Study FB-181
Source:		Journal of Occupational and Environmental Medicine 60 (2018) Nr. 1, S. 36?43 (Language:GB)

Abstract

The aim of this study was to investigate the role of occupational and nonoccupational ultraviolet (UV)-exposure concerning the development of basal cell carcinoma (BCC). We undertook a population-based multicenter case-control study. Patients with first incident BCC (n = 836) were propensity score matched by age and sex to controls without skin cancer (n = 836). Sociodemographic characteristics, clinical characteristics, and lifetime UV-exposure were assessed by trained investigators. The differential estimation of occupational and nonoccupational UV-exposure dosages was based on validated instruments and established reference values. Associations were assessed using multivariable-adjusted conditional logistic regression models. Individuals with high levels of occupational UV-exposure were at significantly increased BCC-risk compared with individuals with low [odds ratio (OR) 1.84; 95% confidence interval (95% CI) 1.19 to 2.83 and moderate (OR 1.97; 95% CI 1.20 to 3.22)] occupational UV-exposure. Nonoccupational UV-exposure was not independently associated with BCC. Skin cancer prevention strategies should be expanded to the occupational setting.

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